TY - JOUR
T1 - Longitudinal analysis of carcinogenic human papillomavirus infection and associated cytologic abnormalities in the Guanacaste natural history study
T2 - Looking ahead to cotesting
AU - Markt, Sarah Coseo
AU - Rodriguez, Ana C.
AU - Burk, Robert D.
AU - Hildesheim, Allan
AU - Herrero, Rolando
AU - Wacholder, Sholom
AU - Hutchinson, Martha
AU - Schiffman, Mark
N1 - Funding Information:
Financial support. This work was supported in part by the National Institutes of Health research training grant (NIH, R25 CA098566 to S.C.M.). The Guanacaste Project was supported by National Cancer Institute, NIH, Department of Health and Human Services (NO1-CP-21081, NO1-CP-33061, NO1-CP-40542, and NO1-CP-506535).
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in a 7-year prospective study of 2500 women in Guanacaste, Costa Rica. Methods. At each semiannual or annual visit, cervical specimens were screened using liquid-based cytology and tested for >40 HPV types with use of MY09/MY11 L1 degenerate primer polymerase chain reaction-based methods. On the basis of previous work, we separated prevalent and newly detected infections in younger and older women. Results. Among newly detected HPV- and/or cytology-positive events, HPV and cytology appeared together ∼60% of the time; when discordant, HPV tended to appear before cytology in younger and older women. Combining newly and prevalently detected events, HPV and cytology disappeared at the same time >70% of the time. When discordant, HPV tended to disappear after cytology in younger and older women. Conclusions. Detection of HPV DNA and associated cytological abnormalities tend to come and leave together; however, when discordant, detection of HPV DNA tends to precede and/or last longer than associated cytologic abnormalities.
AB - Background. Few studies have addressed the timing of cervical cytologic abnormalities and human papillomavirus (HPV) positivity during the course of an infection. It remains largely unknown how infections detected by HPV and cytology wax and wane relative to each other. The aim of this analysis was to assess the longitudinal relationship of abnormal cytology and HPV positivity in a 7-year prospective study of 2500 women in Guanacaste, Costa Rica. Methods. At each semiannual or annual visit, cervical specimens were screened using liquid-based cytology and tested for >40 HPV types with use of MY09/MY11 L1 degenerate primer polymerase chain reaction-based methods. On the basis of previous work, we separated prevalent and newly detected infections in younger and older women. Results. Among newly detected HPV- and/or cytology-positive events, HPV and cytology appeared together ∼60% of the time; when discordant, HPV tended to appear before cytology in younger and older women. Combining newly and prevalently detected events, HPV and cytology disappeared at the same time >70% of the time. When discordant, HPV tended to disappear after cytology in younger and older women. Conclusions. Detection of HPV DNA and associated cytological abnormalities tend to come and leave together; however, when discordant, detection of HPV DNA tends to precede and/or last longer than associated cytologic abnormalities.
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U2 - 10.1093/infdis/jir746
DO - 10.1093/infdis/jir746
M3 - Article
C2 - 22147792
AN - SCOPUS:84855867157
SN - 0022-1899
VL - 205
SP - 498
EP - 505
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -