Abstract
We report the safety and immunogenicity of a double lysine and pantothenate auxotroph of Mycobacterium tuberculosis in mice. The ΔlysA ΔpanCD mutant is completely attenuated in immunocompromised SCID and gamma interferon knockout mice yet induces short-term and long-term protection in immunocompetent and CD4-deficient mice following single-dose subcutaneous vaccination.
Original language | English (US) |
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Pages (from-to) | 1196-1203 |
Number of pages | 8 |
Journal | Infection and immunity |
Volume | 73 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2005 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases