Lipoic acid stimulates cAMP production in T lymphocytes and NK cells

R. V. Schillace, N. Pisenti, N. Pattamanuch, S. Galligan, G. H. Marracci, D. N. Bourdette, D. W. Carr

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The anti-oxidant lipoic acid (LA) potently suppresses clinical and pathologic disease in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis, by inhibiting the migration of pathogenic T cells to the spinal cord. The mechanism by which this occurs is largely unknown. In this report we demonstrate that LA induces increases in cyclic AMP, a known immunosuppressant, in human T cells. The increase in cAMP is associated with increased adenylyl cyclase activity and is partially blocked by prostanoid receptor antagonists. We present evidence that LA also stimulates cAMP production in natural killer (NK) cells. This novel mechanism of action is highly relevant to the immunomodulatory effects of LA and provides further support for the study of LA as a therapeutic agent for multiple sclerosis and other autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)259-264
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Mar 2 2007
Externally publishedYes


  • Lipoic acid
  • Lymphocyte
  • NK cell
  • cAMP

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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