Lipid antioxidant properties of naloxone in vitro

Kinga Koréh; Myron L. Seligman; Eugene S. Flamm; Harry B. Demopoulos

doi:10.1016/S0006-291X(81)80155-6

Lipid antioxidant properties of naloxone in vitro

Kinga Koréh, Myron L. Seligman, Eugene S. Flamm, Harry B. Demopoulos

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The results of this study indicate that naloxone diminishes ironinitiated and catalyzed peroxidation in liposomes in a concentration-dependent manner. This supports the hypothesis that the action of naloxone in vivo during amelioration of spinal cord trauma and hemorrhagic shock may substantially involve its lipid antioxidant properties.

Original language	English (US)
Pages (from-to)	1317-1322
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	102
Issue number	4
DOIs	https://doi.org/10.1016/S0006-291X(81)80155-6
State	Published - Oct 30 1981
Externally published	Yes

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/S0006-291X(81)80155-6

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title = "Lipid antioxidant properties of naloxone in vitro",

abstract = "The results of this study indicate that naloxone diminishes ironinitiated and catalyzed peroxidation in liposomes in a concentration-dependent manner. This supports the hypothesis that the action of naloxone in vivo during amelioration of spinal cord trauma and hemorrhagic shock may substantially involve its lipid antioxidant properties.",

author = "Kinga Kor{\'e}h and Seligman, {Myron L.} and Flamm, {Eugene S.} and Demopoulos, {Harry B.}",

note = "Funding Information: We gratefully acknowledge the technical assistance of Mr. Milton G. Smith. We also wish to express our thanks to Endo Laboratories for their generous gift of naloxone. This work was supported by NINDS Grant No. 2P50 NS10164-08 (NIH) and Pioneer Systems, Inc., Puritan Fashions, Inc. and the Glenn Foundation.",

year = "1981",

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day = "30",

doi = "10.1016/S0006-291X(81)80155-6",

language = "English (US)",

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journal = "Biochemical and Biophysical Research Communications",

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T1 - Lipid antioxidant properties of naloxone in vitro

AU - Koréh, Kinga

AU - Seligman, Myron L.

AU - Flamm, Eugene S.

AU - Demopoulos, Harry B.

N1 - Funding Information: We gratefully acknowledge the technical assistance of Mr. Milton G. Smith. We also wish to express our thanks to Endo Laboratories for their generous gift of naloxone. This work was supported by NINDS Grant No. 2P50 NS10164-08 (NIH) and Pioneer Systems, Inc., Puritan Fashions, Inc. and the Glenn Foundation.

PY - 1981/10/30

Y1 - 1981/10/30

N2 - The results of this study indicate that naloxone diminishes ironinitiated and catalyzed peroxidation in liposomes in a concentration-dependent manner. This supports the hypothesis that the action of naloxone in vivo during amelioration of spinal cord trauma and hemorrhagic shock may substantially involve its lipid antioxidant properties.

AB - The results of this study indicate that naloxone diminishes ironinitiated and catalyzed peroxidation in liposomes in a concentration-dependent manner. This supports the hypothesis that the action of naloxone in vivo during amelioration of spinal cord trauma and hemorrhagic shock may substantially involve its lipid antioxidant properties.

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U2 - 10.1016/S0006-291X(81)80155-6

DO - 10.1016/S0006-291X(81)80155-6

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 4

ER -

Lipid antioxidant properties of naloxone in vitro

Abstract

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