Linked sets of antinuclear antibodies: what do they mean?

J. E. Craft, J. A. Hardin

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Among the many antinuclear antibodies found among patients with systemic lupus erythematosus, a subset predominates in terms of frequency of occurrence and titer. These antibodies include anti-DNA, antihistone, anti-U1 RNP, anti-Sm and anti-Ro and they tend to occur in linked sets which correspond to their autoantigenic epitopes on the nucleosome, the U1 snRNP, and the Ro particle. This pattern of occurrence suggests that these nucleoprotein structures elicit at least some of the autoimmune responses in this disease.

Original languageEnglish (US)
Pages (from-to)106-109
Number of pages4
JournalJournal of Rheumatology
Volume14 Suppl 13
StatePublished - Jun 1 1987

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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