Lessons from the niche for generation and expansion of hematopoietic stem cells

Teresa V. Bowman; Leonard I. Zon

doi:10.1016/j.ddstr.2009.06.003

Lessons from the niche for generation and expansion of hematopoietic stem cells

Teresa V. Bowman, Leonard I. Zon

Research output: Contribution to journal › Review article › peer-review

13 Scopus citations

Abstract

Hematopoietic stem cells (HSCs) are used clinically to treat human blood-related genetic diseases and leukemias, but the availability of this therapy is constrained by the limiting number of transplantable HSCs. Previous strategies to expand HSCs in vitro resulted in precocious differentiation and reduced transplant efficiency. In vivo analysis of the mechanisms utilized by fetal and adult niches to control HSCs can be mimicked for therapeutic use. This review summarizes the latest research on the in vivo HSC niche and the clinical applications of this knowledge to promote ex vivo expansion and direct de novo generation of HSCs.

Original language	English (US)
Pages (from-to)	135-140
Number of pages	6
Journal	Drug Discovery Today: Therapeutic Strategies
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/j.ddstr.2009.06.003
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ddstr.2009.06.003

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abstract = "Hematopoietic stem cells (HSCs) are used clinically to treat human blood-related genetic diseases and leukemias, but the availability of this therapy is constrained by the limiting number of transplantable HSCs. Previous strategies to expand HSCs in vitro resulted in precocious differentiation and reduced transplant efficiency. In vivo analysis of the mechanisms utilized by fetal and adult niches to control HSCs can be mimicked for therapeutic use. This review summarizes the latest research on the in vivo HSC niche and the clinical applications of this knowledge to promote ex vivo expansion and direct de novo generation of HSCs.",

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AU - Zon, Leonard I.

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AB - Hematopoietic stem cells (HSCs) are used clinically to treat human blood-related genetic diseases and leukemias, but the availability of this therapy is constrained by the limiting number of transplantable HSCs. Previous strategies to expand HSCs in vitro resulted in precocious differentiation and reduced transplant efficiency. In vivo analysis of the mechanisms utilized by fetal and adult niches to control HSCs can be mimicked for therapeutic use. This review summarizes the latest research on the in vivo HSC niche and the clinical applications of this knowledge to promote ex vivo expansion and direct de novo generation of HSCs.

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JO - Drug Discovery Today: Therapeutic Strategies

JF - Drug Discovery Today: Therapeutic Strategies

IS - 4

ER -

Lessons from the niche for generation and expansion of hematopoietic stem cells

Abstract

ASJC Scopus subject areas

UN SDGs

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