Abstract
Noninvasive monitoring of blood flow in retinal circulation will reveal the progression and treatment of ocular disorders, such as diabetic retinopathy, age-related macular degeneration and glaucoma. A non-invasive and direct BF measurement technique with high spatial-temporal resolution is needed for retinal imaging. Laser speckle imaging (LSI) is such a method. Currently, there are two analysis methods for LSI: spatial statistics LSI (SS-LSI) and temporal statistical LSI (TS-LSI). Comparing these two analysis methods, SS-LSI has higher signal to noise ratio (SNR) and TS- LSI is less susceptible to artifacts from stationary speckle. We proposed a hybrid temporal and spatial analysis method (HTS-LSI) to measure the retinal blood flow. Gas challenge experiment was performed and images were analyzed by HTS-LSI. Results showed that HTS-LSI can not only remove the stationary speckle but also increase the SNR. Under 100% O2, retinal BF decreased by 20-30%. This was consistent with the results observed with laser Doppler technique. As retinal blood flow is a critical physiological parameter and its perturbation has been implicated in the early stages of many retinal diseases, HTS-LSI will be an efficient method in early detection of retina diseases.
| Original language | English (US) |
|---|---|
| Article number | 716304 |
| Journal | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 7163 |
| DOIs | |
| State | Published - 2009 |
| Externally published | Yes |
| Event | Ophthalmic Technologies XIX - San Jose, CA, United States Duration: Jan 24 2009 → Jan 26 2009 |
Keywords
- Hybrid
- Laser speckle imaging
- Retinal blood flow
- Signal to noise ratio
- Spatial statistical
- stationary speckle
- Temporal statistical
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Biomaterials
- Atomic and Molecular Physics, and Optics
- Radiology Nuclear Medicine and imaging
