Laparoscopic-assisted versus open pancreaticoduodenectomy: Early favorable physical quality-of-life measures

Russell C. Langan, Jay A. Graham, Anne B. Chin, Aaron J. Rubinstein, Kesha Oza, Jeff A. Nusbaum, John Smirniotopoulos, Reilly Kayser, Reena Jha, Nadim Haddad, Firas Al-Kawas, John Carroll, Jane Hanna, Ann Parker, Waddah B. Al-Refaie, Lynt B. Johnson

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Background We compared outcomes and postpancreatectomy quality of life (QOL) in paired cohorts of patients undergoing conventional open pancreaticoduodenectomy (OPD) or laparoscopic-assisted pancreaticoduodenectomy (LAPD). Methods Comparative analysis of QOL was performed in a matched cohort of 53 patients after OPD or LAPD between 2010 and 2013. The Medical Outcomes Study Short Form-36 Health Survey and the Karnofsky score were used. Results Physical component score, mental component score, and Karnofsky scores were calculated at multiple time points for OPD (n = 25) and LAPD (n = 28). Operative times, complications, and readmission rates were equivalent. Time to starting adjuvant therapy trended toward clinical importance in LAPD (61 vs 110 days, P =.0878). Duration of stay was less in LAPD (7.10 vs 9.44 days, P =.02). LAPD had a superior QOL centered on functional status compared with OPD (physical component score 49.09 vs 38.4, P =.04; Karnofsky 92.22 vs 66.92%, P =.003). These statistical differences were not observed beyond 6 months. Conclusion LAPD provided a more favorable QOL within the first 6 months and shorter length of stay compared with conventional OPD. LAPD may serve as an alternative operative therapy to potentially minimize delays in receipt of and enhance tolerability of adjuvant therapies.

Original languageEnglish (US)
Pages (from-to)379-384
Number of pages6
JournalSurgery (United States)
Issue number2
StatePublished - Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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