L-Arginine Improves Cognitive Impairment in Hypertensive Frail Older Adults

Pasquale Mone, Antonella Pansini, Stanislovas S. Jankauskas, Fahimeh Varzideh, Urna Kansakar, Angela Lombardi, Valentina Trimarco, Salvatore Frullone, Gaetano Santulli

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Cognitive impairment is a prevailing event in hypertensive patients and in frail older adults. Endothelial dysfunction has been shown to underlie both hypertension and cognitive dysfunction. Our hypothesis is that L-Arginine, which is known to ameliorate endothelial dysfunction, could counteract cognitive impairment in a high-risk population of hypertensive frail older adults. We designed a clinical trial to verify the effects of 4-weeks oral supplementation of L-Arginine on global cognitive function of hypertensive frail older patients. The study was successfully completed by 35 frail hypertensive elderly patients assigned to L-Arginine and 37 assigned to placebo. At follow-up, we found a significant difference in the Montreal Cognitive Assessment (MoCA) test score between the L-Arginine treated group and placebo (p: 0.0178). Moreover, we demonstrated that L-Arginine significantly attenuates Angiotensin II-induced mitochondrial oxidative stress in human endothelial cells. In conclusion, our findings indicate for the first time that oral L-Arginine supplementation significantly improves cognitive impairment in frail hypertensive older adults. Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT04962841.

Original languageEnglish (US)
Article number868521
JournalFrontiers in Cardiovascular Medicine
StatePublished - Apr 12 2022


  • L-Arg
  • L-Arginine
  • cardiac rehabilitation
  • cognitive impairment
  • endothelial (dys)function
  • frail adults
  • frailty

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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