KIFC3 promotes mitotic progression and integrity of the central spindle in cytokinesis

Jeannette Nachbar, Francisco Laźaro-Diéguez, Rytis Prekeris, David Cohen, Anne Mus̈ch

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Kinesin-14 motor proteins play a variety of roles during metaphase and anaphase. However, it is not known whether members of this family of motors also participate in the dramatic changes in mitotic spindle organization during the transition from telophase to cytokinesis. We have identified the minus-end-directed motor, KIFC3, as an important contributor to central bridge morphology at this stage. KIFC3's unique motor-dependent localization at the central bridge allows it to congress microtubules, promoting efficient progress through cytokinesis. Conversely, when KIFC3 function is perturbed, abscission is delayed, and the central bridge is both widened and extended. Examination of KIFC3 on growing microtubules in interphase indicates that it caps microtubules released from the centrosome, both in the region of the centrosome and in the cell periphery. In line with other kinesin-14 family members, KIFC3 may guide free microtubules to their destination at the bridge and/or may slide and crosslink central bridge microtubules in order to stage the cells for abscission.

Original languageEnglish (US)
Pages (from-to)426-433
Number of pages8
JournalCell Cycle
Issue number3
StatePublished - Feb 1 2014


  • Abscission
  • Cytokinesis
  • KIFC3
  • Kinesin-14
  • Mitotic kinesin

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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