TY - JOUR
T1 - KHSV- EBV- post-transplant effusion lymphoma with plasmablastic features
T2 - Variant of primary effusion lymphoma?
AU - Lambe, Jennifer S.
AU - Oble, Darryl A.
AU - Nandula, Subhadra V.
AU - Sevilla, Deborah W.
AU - Colovai, Adriana I.
AU - Mansukhani, Mahesh
AU - Chari, Ajai
AU - Murty, Vundavalli V.
AU - Alobeid, Bachir
AU - Bhagat, Govind
PY - 2009
Y1 - 2009
N2 - Primary effusion lymphoma (PEL) is a rare type of B-cell non-Hodgkin lymphoma (NHL), which predominantly occurs in HIV-infected individuals, and is pathogenetically linked with Kaposi sarcoma (KS)-associated herpes virus/human herpes virus-8 (KSHV/HHV-8) infection with or without evidence of Epstein-Barr virus (EBV) co-infection. Although uncommon, PELs have been reported in immunocompetent patients and recipients of solid organ allografts. Rare cases of KSHV- EBV+ post-transplant effusion lymphomas resembling PEL have also been described, as have KSHV- EBV- effusion lymphomas, the latter including those arising in individuals with chronic liver disease. We report a unique KSHV- EBV- post-transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV - individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c-MYC.
AB - Primary effusion lymphoma (PEL) is a rare type of B-cell non-Hodgkin lymphoma (NHL), which predominantly occurs in HIV-infected individuals, and is pathogenetically linked with Kaposi sarcoma (KS)-associated herpes virus/human herpes virus-8 (KSHV/HHV-8) infection with or without evidence of Epstein-Barr virus (EBV) co-infection. Although uncommon, PELs have been reported in immunocompetent patients and recipients of solid organ allografts. Rare cases of KSHV- EBV+ post-transplant effusion lymphomas resembling PEL have also been described, as have KSHV- EBV- effusion lymphomas, the latter including those arising in individuals with chronic liver disease. We report a unique KSHV- EBV- post-transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV - individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c-MYC.
KW - Cytogenetics
KW - Isochromosome 12p
KW - Post-transplant
KW - Primary effusion lymphoma
KW - c-MYC
UR - http://www.scopus.com/inward/record.url?scp=73349141124&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73349141124&partnerID=8YFLogxK
U2 - 10.1002/hon.892
DO - 10.1002/hon.892
M3 - Article
C2 - 19337983
AN - SCOPUS:73349141124
SN - 0278-0232
VL - 27
SP - 203
EP - 210
JO - Hematological Oncology
JF - Hematological Oncology
IS - 4
ER -