TY - JOUR
T1 - Isospora belli infection
T2 - Treatment with pyrimethamine
AU - Weiss, L. M.
AU - Perlman, D. C.
AU - Sherman, J.
AU - Tanowitz, H.
AU - Wittner, M.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Isosporiasis is an uncommon but important diarrheal disease of humans that, like cryptosporidiosis, is life-threatening in patients with the acquired immunodeficiency syndrome (AIDS). Isospora belli infection responds rapidly to therapy with trimethoprim-sulfamethoxazole, but patients with AIDS have a high rate of adverse reactions to this therapy. The cases of two patients with AIDS, sulfonamide allergy, and I. belli infection are reported. They were treated successfully with pyrimethamine alone, 75 mg/d, and recurrence was prevented with daily pyrimethamine therapy, 25 mg/d. In patients with AIDS with sulfonamide allergy or intolerance, pyrimethamine alone seems to be a reasonable alternative therapy for I. belli infection.
AB - Isosporiasis is an uncommon but important diarrheal disease of humans that, like cryptosporidiosis, is life-threatening in patients with the acquired immunodeficiency syndrome (AIDS). Isospora belli infection responds rapidly to therapy with trimethoprim-sulfamethoxazole, but patients with AIDS have a high rate of adverse reactions to this therapy. The cases of two patients with AIDS, sulfonamide allergy, and I. belli infection are reported. They were treated successfully with pyrimethamine alone, 75 mg/d, and recurrence was prevented with daily pyrimethamine therapy, 25 mg/d. In patients with AIDS with sulfonamide allergy or intolerance, pyrimethamine alone seems to be a reasonable alternative therapy for I. belli infection.
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U2 - 10.7326/0003-4819-109-6-474
DO - 10.7326/0003-4819-109-6-474
M3 - Article
C2 - 3261956
AN - SCOPUS:0023726660
SN - 0003-4819
VL - 109
SP - 474
EP - 475
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
IS - 6
ER -
