Investigating co-evolution of functionally associated phosphosites in human

Zhi Liu, Guangyong Zheng, Xiao Dong, Zhen Wang, Beili Ying, Yang Zhong, Yixue Li

Research output: Contribution to journalArticlepeer-review


Phosphorylation is essential for protein function and signal transduction in eukaryotic cells. With the rapid development of mass spectrometry technology, a large number of phosphosites are identified. However, high-throughput methods of functional characterization for phosphosites are still scarce. In this study, we inspected if the co-evolution property can be used as an indicator to explore function of phosphosites through investigating co-evolutionary relationship between functionally associated phosphosites in human. In practice, the evolution attributes of phosphosites were represented with phylogenetic profiles, and then co-evolutionary correlations of functionally associated phosphosites were detected on three levels: (1) phosphosites within one protein; (2) phosphosites in different proteins participating in the same signal transduction pathways, and (3) general phosphosites. Results of the detection show that co-evolution is a general property of functionally associated phosphosites. This finding suggests to some degree that it is feasible to use the co-evolution property in exploring the function of phosphosites and investigating the functional association between them.

Original languageEnglish (US)
Pages (from-to)1217-1223
Number of pages7
JournalMolecular Genetics and Genomics
StatePublished - 2014
Externally publishedYes


  • Co-evolution
  • Functional association
  • Phosphorylation site
  • Phylogenetic profile
  • Post-translational modification

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics


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