Invariant NKT cell regulation of autoimmunity

Alberto Molano; Steven A. Porcelli

doi:10.1016/j.ddmec.2006.05.002

Invariant NKT cell regulation of autoimmunity

Alberto Molano, Steven A. Porcelli

Microbiology & Immunology

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Accumulating evidence supports the notion that invariant NKT cells that recognize glycolipids presented by CD1d can play a role in the regulation of certain types of autoimmunity. Focusing mainly on studies of type 1 diabetes and several other common autoimmune diseases, we present an overview of the available knowledge and current speculations on the immunoregulatory mechanisms of NKT cells. Targeting invariant NKT cells with specific glycolipids that bind to CD1d might prove to be a powerful means of modulating autoimmunity.

Original language	English (US)
Pages (from-to)	193-198
Number of pages	6
Journal	Drug Discovery Today: Disease Mechanisms
Volume	3
Issue number	2
DOIs	https://doi.org/10.1016/j.ddmec.2006.05.002
State	Published - 2006

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ddmec.2006.05.002

Cite this

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AB - Accumulating evidence supports the notion that invariant NKT cells that recognize glycolipids presented by CD1d can play a role in the regulation of certain types of autoimmunity. Focusing mainly on studies of type 1 diabetes and several other common autoimmune diseases, we present an overview of the available knowledge and current speculations on the immunoregulatory mechanisms of NKT cells. Targeting invariant NKT cells with specific glycolipids that bind to CD1d might prove to be a powerful means of modulating autoimmunity.

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Invariant NKT cell regulation of autoimmunity

Abstract

ASJC Scopus subject areas

UN SDGs

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