Intrinsic and extrinsic mechanisms of dendritic morphogenesis

Xintong Dong, Kang Shen, Hannes E. Bülow

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


The complex, branched morphology of dendrites is a cardinal feature of neurons and has been used as a criterion for cell type identification since the beginning of neurobiology. Regulated dendritic outgrowth and branching during development form the basis of receptive fields for neurons and are essential for the wiring of the nervous system. The cellular and molecular mechanisms of dendritic morphogenesis have been an intensely studied area. In this review, we summarize the major experimental systems that have contributed to our understandings of dendritic development as well as the intrinsic and extrinsic mechanisms that instruct the neurons to form cell type-specific dendritic arbors.

Original languageEnglish (US)
Pages (from-to)271-300
Number of pages30
JournalAnnual review of physiology
StatePublished - Feb 1 2015


  • Branching
  • Dendrite
  • Development
  • Neuron
  • Receptor-ligand interaction
  • Self-avoidance
  • Transcriptional regulation

ASJC Scopus subject areas

  • Physiology


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