Intravascular Ultrasound Characterization of a Tissue-Engineered Vascular Graft in an Ovine Model

Victoria K. Pepper, Elizabeth S. Clark, Cameron A. Best, Ekene A. Onwuka, Tadahisa Sugiura, Eric D. Heuer, Lilamarie E. Moko, Shinka Miyamoto, Hideki Miyachi, Darren P. Berman, Sharon L. Cheatham, Joanne L. Chisolm, Toshiharu Shinoka, Christopher K. Breuer, John P. Cheatham

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Patients who undergo implantation of a tissue-engineered vascular graft (TEVG) for congenital cardiac anomalies are monitored with echocardiography, followed by magnetic resonance imaging or angiography when indicated. While these methods provide data regarding the lumen, minimal information regarding neotissue formation is obtained. Intravascular ultrasound (IVUS) has previously been used in a variety of conditions to evaluate the vessel wall. The purpose of this study was to evaluate the utility of IVUS for evaluation of TEVGs in our ovine model. Eight sheep underwent implantation of TEVGs either unseeded or seeded with bone marrow-derived mononuclear cells. Angiography, IVUS, and histology were directly compared. Endothelium, tunica media, and graft were identifiable on IVUS and histology at multiple time points. There was strong agreement between IVUS and angiography for evaluation of luminal diameter. IVUS offers a valuable tool to evaluate the changes within TEVGs, and clinical translation of this application is warranted.

Original languageEnglish (US)
Pages (from-to)128-138
Number of pages11
JournalJournal of Cardiovascular Translational Research
Issue number2
StatePublished - Apr 1 2017
Externally publishedYes


  • Angiography
  • IVUS
  • Intravascular ultrasound
  • Neotissue
  • Stenosis
  • TEVG
  • Tissue-engineered vascular graft

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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