Intracranial metastasis in fibrolamellar hepatocellular carcinoma

William J. Hammond, Gadi Lalazar, James A. Saltsman, Benjamin A. Farber, Enrico Danzer, Tshering C. Sherpa, Charles D. Banda, Jeffrey R. Andolina, Sasan Karimi, Cameron W. Brennan, Michael S. Torbenson, Michael P. La Quaglia, Sanford M. Simon

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare liver malignancy in adolescents and young adults. Surgery is the mainstay of therapy for primary and metastatic disease. Most patients relapse, with development of both local and distant metastases. Brain metastases from solid tumors are rare in the pediatric and young adult population. Here, we document three patients with brain metastases from FLHCC, confirmed by histology and molecular characterization of the chimeric fusion DNAJB1–PRKACA, each necessitating neurosurgical intervention. These observations highlight the ability of FLHCC to metastasize to the brain and suggest the need for surveillance neuroimaging for patients with advanced-stage disease.

Original languageEnglish (US)
Article numbere26919
JournalPediatric Blood and Cancer
Issue number4
StatePublished - Apr 2018
Externally publishedYes


  • adolescent and young adult tumors
  • brain
  • fibrolamellar
  • liver
  • rare tumors
  • tumor biology
  • tumors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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