Intracerebral Hemorrhage Outcomes in Patients with Systemic Cancer

Santosh B. Murthy, Aditi Shastri, Alexander E. Merkler, Daniel F. Hanley, Wendy C. Ziai, Matthew E. Fink, Costantino Iadecola, Hooman Kamel, Babak B. Navi

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background Single-center studies suggest that patients with cancer have similar outcomes after intracerebral hemorrhage (ICH) compared to patients without cancer. However, these studies were limited by small sample sizes and high rates of intratumoral hemorrhage. Our hypothesis was that systemic cancer patients without brain involvement fare worse after ICH than patients without cancer. Methods We identified all patients diagnosed with spontaneous ICH from 2002 to 2011 in the Nationwide Inpatient Sample. Our predictor variable was systemic cancer. Our primary outcome was discharge disposition, dichotomized into favorable discharge (home/self-care or rehabilitation) or unfavorable discharge (nursing facility, hospice, or death). We used logistic regression to compare outcomes and performed secondary analyses by cancer subtype (i.e., nonmetastatic solid tumors, nonmetastatic hematologic tumors, and metastatic solid or hematologic tumors). Results Among 597,046 identified ICH patients, 22,394 (3.8%) had systemic cancer. Stroke risk factors such as hypertension and diabetes were more common in patients without cancer, whereas anticoagulant use and higher Charlson comorbidity scores were more common among cancer patients. In multivariate logistic regression analysis adjusted for demographics, comorbidities, and hospital-level characteristics, patients with cancer had higher odds of death (OR 1.62, 95% CI 1.56-1.69) and lower odds of favorable discharge (OR .59, 95% CI .56-.63) than patients without cancer. Among cancer groups, patients with nonmetastatic hematologic tumors and those with metastatic disease fared the worst. Conclusions Patients with systemic cancer have higher mortality and less favorable discharge outcomes after ICH than patients without cancer. Cancer subtype may influence outcomes after ICH.

Original languageEnglish (US)
Pages (from-to)2918-2924
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Issue number12
StatePublished - Dec 1 2016


  • Intracerebral hemorrhage
  • cancer
  • clinical outcomes
  • malignancy

ASJC Scopus subject areas

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Intracerebral Hemorrhage Outcomes in Patients with Systemic Cancer'. Together they form a unique fingerprint.

Cite this