Abstract
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus. (Figure presented.).
Original language | English (US) |
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Pages (from-to) | 3041-3051 |
Number of pages | 11 |
Journal | Journal of Physiology |
Volume | 595 |
Issue number | 10 |
DOIs | |
State | Published - May 15 2017 |
Externally published | Yes |
Keywords
- Calcium
- Diabetes mellitus
- Heart failure
- Hypertension
- IP3R
- Intracellular calcium release channels
- RyR
- excitation-contraction coupling
ASJC Scopus subject areas
- Physiology