Intestinal transplantation: Indications, results and strategy

Olivier Goulet, Florence Lacaille, Dominique Jan, Claude Ricour

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


The term 'intestinal failure' is now often used to describe gastrointestinal function insufficient to satisfy body nutrient and fluid requirements. The first recognized condition of intestinal failure was short bowel syndrome. Severe motility disorders such as chronic intestinal pseudo-obstruction syndrome in children as well as congenital intractable intestinal mucosa disorders are also forms of intestinal failure, because no curative treatment for these diseases is yet available. Parenteral nutrition and home parenteral nutrition remain the mainstay of therapy for intestinal failure, whether it is partial or total, provisional or permanent. However, some patients develop complications while receiving standard therapy for intestinal failure and are considered for intestinal transplantation. Indeed, recent advances in immunosuppressive treatment and the better monitoring and control of acute rejection have brought intestinal transplantation into the realm of standard treatment for intestinal failure. Although it has been used in humans for the past two decades, this procedure has had a slow learning curve. According to the current results, this challenging procedure may be performed in children or adults, only under certain conditions. (C) 2000 Lippincott Williams and Wilkins.

Original languageEnglish (US)
Pages (from-to)329-338
Number of pages10
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Issue number5
StatePublished - 2000
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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