Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals

George Vlad; Flavia Piazza; Adriana Colovai; Raffaello Cortesini; Fatima Della Pietra; Nicole Suciu-Foca; John S. Manavalan

doi:10.1016/S0198-8859(03)00040-5

Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals

George Vlad, Flavia Piazza, Adriana Colovai, Raffaello Cortesini, Fatima Della Pietra, Nicole Suciu-Foca, John S. Manavalan

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

A characteristic of human immunodeficiency virus infected individuals is an impairment of immune responses, which can result in opportunistic infections. Elevated levels of interleukin-10 (IL-10), produced by virally infected monocytes, are found in the sera of HIV infected individuals. Such elevated levels have been associated with the impaired function of CD4⁺ and CD8⁺ T cells, and antigen presenting cells (APC), such as monocytes. IL-10 has been reported to upregulate the cell surface expression of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells. This study demonstrates that the decreased antigen presenting ability of monocytes in HIV⁺ individuals is in part due to the upregulation of ILT4 on the monocytes caused by the elevated serum IL-10 levels seen in these individuals.

Original language	English (US)
Pages (from-to)	483-489
Number of pages	7
Journal	Human Immunology
Volume	64
Issue number	5
DOIs	https://doi.org/10.1016/S0198-8859(03)00040-5
State	Published - May 1 2003
Externally published	Yes

Keywords

HIV
ILT4
Interleukin-10
Monocytes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0198-8859(03)00040-5

Cite this

@article{ab36ce8331884213816bd5b0ea608d87,

title = "Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals",

abstract = "A characteristic of human immunodeficiency virus infected individuals is an impairment of immune responses, which can result in opportunistic infections. Elevated levels of interleukin-10 (IL-10), produced by virally infected monocytes, are found in the sera of HIV infected individuals. Such elevated levels have been associated with the impaired function of CD4+ and CD8+ T cells, and antigen presenting cells (APC), such as monocytes. IL-10 has been reported to upregulate the cell surface expression of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells. This study demonstrates that the decreased antigen presenting ability of monocytes in HIV+ individuals is in part due to the upregulation of ILT4 on the monocytes caused by the elevated serum IL-10 levels seen in these individuals.",

keywords = "HIV, ILT4, Interleukin-10, Monocytes",

author = "George Vlad and Flavia Piazza and Adriana Colovai and Raffaello Cortesini and {Della Pietra}, Fatima and Nicole Suciu-Foca and Manavalan, {John S.}",

note = "Funding Information: We thank Eric Ho and Chris Chang for their help. This work was supported by grants from the NIH and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.",

year = "2003",

month = may,

day = "1",

doi = "10.1016/S0198-8859(03)00040-5",

language = "English (US)",

volume = "64",

pages = "483--489",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals

AU - Vlad, George

AU - Piazza, Flavia

AU - Colovai, Adriana

AU - Cortesini, Raffaello

AU - Della Pietra, Fatima

AU - Suciu-Foca, Nicole

AU - Manavalan, John S.

N1 - Funding Information: We thank Eric Ho and Chris Chang for their help. This work was supported by grants from the NIH and the Interuniversitary Organ Transplantation Consortium, Rome, Italy.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - A characteristic of human immunodeficiency virus infected individuals is an impairment of immune responses, which can result in opportunistic infections. Elevated levels of interleukin-10 (IL-10), produced by virally infected monocytes, are found in the sera of HIV infected individuals. Such elevated levels have been associated with the impaired function of CD4+ and CD8+ T cells, and antigen presenting cells (APC), such as monocytes. IL-10 has been reported to upregulate the cell surface expression of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells. This study demonstrates that the decreased antigen presenting ability of monocytes in HIV+ individuals is in part due to the upregulation of ILT4 on the monocytes caused by the elevated serum IL-10 levels seen in these individuals.

AB - A characteristic of human immunodeficiency virus infected individuals is an impairment of immune responses, which can result in opportunistic infections. Elevated levels of interleukin-10 (IL-10), produced by virally infected monocytes, are found in the sera of HIV infected individuals. Such elevated levels have been associated with the impaired function of CD4+ and CD8+ T cells, and antigen presenting cells (APC), such as monocytes. IL-10 has been reported to upregulate the cell surface expression of the inhibitory receptors ILT3 and ILT4 on monocytes and dendritic cells. This study demonstrates that the decreased antigen presenting ability of monocytes in HIV+ individuals is in part due to the upregulation of ILT4 on the monocytes caused by the elevated serum IL-10 levels seen in these individuals.

KW - HIV

KW - ILT4

KW - Interleukin-10

KW - Monocytes

UR - http://www.scopus.com/inward/record.url?scp=0037405228&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037405228&partnerID=8YFLogxK

U2 - 10.1016/S0198-8859(03)00040-5

DO - 10.1016/S0198-8859(03)00040-5

M3 - Article

C2 - 12691698

AN - SCOPUS:0037405228

SN - 0198-8859

VL - 64

SP - 483

EP - 489

JO - Human Immunology

JF - Human Immunology

IS - 5

ER -

Interleukin-10 induces the upregulation of the inhibitory receptor ILT4 in monocytes from HIV positive individuals

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this