Integrins, Immunology

Ellen H. De Moll; Joanna Dong; Margeaux Oliva; Yvonne Saenger

doi:10.1007/978-1-4419-0717-2_131

Integrins, Immunology

Ellen H. De Moll, Joanna Dong, Margeaux Oliva, Yvonne Saenger

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The role of integrins is important for tumor proliferation, angiogenesis, invasion and metastasis. Integrins are the principal receptors for binding most extracellular matrix (ECM) proteins. Integrins serve two major roles in cell function: cell adhesion and cell signaling. There are multiple mechanisms by which integrins can be assessed in the laboratory, and clinical trials with anti-integrin antibodies are ongoing. Tumor cells can use variable integrin expression to increase proliferation and promote metastasis and angiogenesis. There may be a role for integrin blockade in the treatment of tumor growth and metastasis, though successful human trials have not yet been achieved.

Original language	English (US)
Title of host publication	Cancer Therapeutic Targets
Publisher	Springer New York
Pages	285-294
Number of pages	10
Volume	1-2
ISBN (Electronic)	9781441907172
ISBN (Print)	9781441907165
DOIs	https://doi.org/10.1007/978-1-4419-0717-2_131
State	Published - Jan 1 2017
Externally published	Yes

Keywords

Angiogenesis
Extra cellular matrix
Integrin
Therapeutic targets

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1007/978-1-4419-0717-2_131

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AU - De Moll, Ellen H.

AU - Dong, Joanna

AU - Oliva, Margeaux

AU - Saenger, Yvonne

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N2 - The role of integrins is important for tumor proliferation, angiogenesis, invasion and metastasis. Integrins are the principal receptors for binding most extracellular matrix (ECM) proteins. Integrins serve two major roles in cell function: cell adhesion and cell signaling. There are multiple mechanisms by which integrins can be assessed in the laboratory, and clinical trials with anti-integrin antibodies are ongoing. Tumor cells can use variable integrin expression to increase proliferation and promote metastasis and angiogenesis. There may be a role for integrin blockade in the treatment of tumor growth and metastasis, though successful human trials have not yet been achieved.

AB - The role of integrins is important for tumor proliferation, angiogenesis, invasion and metastasis. Integrins are the principal receptors for binding most extracellular matrix (ECM) proteins. Integrins serve two major roles in cell function: cell adhesion and cell signaling. There are multiple mechanisms by which integrins can be assessed in the laboratory, and clinical trials with anti-integrin antibodies are ongoing. Tumor cells can use variable integrin expression to increase proliferation and promote metastasis and angiogenesis. There may be a role for integrin blockade in the treatment of tumor growth and metastasis, though successful human trials have not yet been achieved.

KW - Angiogenesis

KW - Extra cellular matrix

KW - Integrin

KW - Therapeutic targets

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BT - Cancer Therapeutic Targets

PB - Springer New York

ER -

Integrins, Immunology

Abstract

Keywords

ASJC Scopus subject areas

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