Integrins, Immunology

Ellen H. De Moll, Joanna Dong, Margeaux Oliva, Yvonne Saenger

Research output: Chapter in Book/Report/Conference proceedingChapter


The role of integrins is important for tumor proliferation, angiogenesis, invasion and metastasis. Integrins are the principal receptors for binding most extracellular matrix (ECM) proteins. Integrins serve two major roles in cell function: cell adhesion and cell signaling. There are multiple mechanisms by which integrins can be assessed in the laboratory, and clinical trials with anti-integrin antibodies are ongoing. Tumor cells can use variable integrin expression to increase proliferation and promote metastasis and angiogenesis. There may be a role for integrin blockade in the treatment of tumor growth and metastasis, though successful human trials have not yet been achieved.

Original languageEnglish (US)
Title of host publicationCancer Therapeutic Targets
PublisherSpringer New York
Number of pages10
ISBN (Electronic)9781441907172
ISBN (Print)9781441907165
StatePublished - Jan 1 2017
Externally publishedYes


  • Angiogenesis
  • Extra cellular matrix
  • Integrin
  • Therapeutic targets

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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