Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program

Malcolm A. Smith; Richard Gorlick; E. Anders Kolb; Richard Lock; Hernan Carol; John M. Maris; Stephen T. Keir; Christopher L. Morton; C. Patrick Reynolds; Min H. Kang; Janine Arts; Tarig Bashir; Michel Janicot; Raushan T. Kurmasheva; Peter J. Houghton

doi:10.1002/pbc.23319

Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program

Malcolm A. Smith, Richard Gorlick, E. Anders Kolb, Richard Lock, Hernan Carol, John M. Maris, Stephen T. Keir, Christopher L. Morton, C. Patrick Reynolds, Min H. Kang, Janine Arts, Tarig Bashir, Michel Janicot, Raushan T. Kurmasheva, Peter J. Houghton

Pediatrics

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

JNJ-26854165 was originally developed as an activator of p53 capable of inducing apoptosis in cancer cell lines. In vitro, JNJ-26854165 demonstrated cytotoxic activity. The ALL cell line panel had a significantly lower median IC ₅₀ (0.85μM) than the remaining cell lines. In vivo JNJ-26854165 induced significant differences in EFS distribution compared to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable ALL xenografts. Objective responses were observed in 4 of 37 solid tumor xenografts, and 2 of 7 ALL xenografts achieved PR or CR. Responses were noted in xenografts with both mutant and wild-type p53.

Original language	English (US)
Pages (from-to)	329-332
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	59
Issue number	2
DOIs	https://doi.org/10.1002/pbc.23319
State	Published - Aug 2012

Keywords

Developmental therapeutics
JNJ-26854165
Preclinical testing

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/pbc.23319

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Smith, M. A., Gorlick, R., Kolb, E. A., Lock, R., Carol, H., Maris, J. M., Keir, S. T., Morton, C. L., Reynolds, C. P., Kang, M. H., Arts, J., Bashir, T., Janicot, M., Kurmasheva, R. T., & Houghton, P. J. (2012). Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program. Pediatric Blood and Cancer, 59(2), 329-332. https://doi.org/10.1002/pbc.23319

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title = "Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program",

abstract = "JNJ-26854165 was originally developed as an activator of p53 capable of inducing apoptosis in cancer cell lines. In vitro, JNJ-26854165 demonstrated cytotoxic activity. The ALL cell line panel had a significantly lower median IC 50 (0.85μM) than the remaining cell lines. In vivo JNJ-26854165 induced significant differences in EFS distribution compared to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable ALL xenografts. Objective responses were observed in 4 of 37 solid tumor xenografts, and 2 of 7 ALL xenografts achieved PR or CR. Responses were noted in xenografts with both mutant and wild-type p53.",

keywords = "Developmental therapeutics, JNJ-26854165, Preclinical testing",

author = "Smith, {Malcolm A.} and Richard Gorlick and Kolb, {E. Anders} and Richard Lock and Hernan Carol and Maris, {John M.} and Keir, {Stephen T.} and Morton, {Christopher L.} and Reynolds, {C. Patrick} and Kang, {Min H.} and Janine Arts and Tarig Bashir and Michel Janicot and Kurmasheva, {Raushan T.} and Houghton, {Peter J.}",

year = "2012",

month = aug,

doi = "10.1002/pbc.23319",

language = "English (US)",

volume = "59",

pages = "329--332",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

publisher = "Wiley-Liss Inc.",

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T1 - Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program

AU - Smith, Malcolm A.

AU - Gorlick, Richard

AU - Kolb, E. Anders

AU - Lock, Richard

AU - Carol, Hernan

AU - Maris, John M.

AU - Keir, Stephen T.

AU - Morton, Christopher L.

AU - Reynolds, C. Patrick

AU - Kang, Min H.

AU - Arts, Janine

AU - Bashir, Tarig

AU - Janicot, Michel

AU - Kurmasheva, Raushan T.

AU - Houghton, Peter J.

PY - 2012/8

Y1 - 2012/8

N2 - JNJ-26854165 was originally developed as an activator of p53 capable of inducing apoptosis in cancer cell lines. In vitro, JNJ-26854165 demonstrated cytotoxic activity. The ALL cell line panel had a significantly lower median IC 50 (0.85μM) than the remaining cell lines. In vivo JNJ-26854165 induced significant differences in EFS distribution compared to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable ALL xenografts. Objective responses were observed in 4 of 37 solid tumor xenografts, and 2 of 7 ALL xenografts achieved PR or CR. Responses were noted in xenografts with both mutant and wild-type p53.

AB - JNJ-26854165 was originally developed as an activator of p53 capable of inducing apoptosis in cancer cell lines. In vitro, JNJ-26854165 demonstrated cytotoxic activity. The ALL cell line panel had a significantly lower median IC 50 (0.85μM) than the remaining cell lines. In vivo JNJ-26854165 induced significant differences in EFS distribution compared to control in 18 of 37 solid tumors and in 5 of 7 of the evaluable ALL xenografts. Objective responses were observed in 4 of 37 solid tumor xenografts, and 2 of 7 ALL xenografts achieved PR or CR. Responses were noted in xenografts with both mutant and wild-type p53.

KW - Developmental therapeutics

KW - JNJ-26854165

KW - Preclinical testing

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SP - 329

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JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

IS - 2

ER -

Initial testing of JNJ-26854165 (Serdemetan) by the pediatric preclinical testing program

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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