Abstract
Neuroblastoma is the most common solid tumor of infants and carries a poor prognosis especially in advanced stages. The present recommended therapies carry a high risk of side effects that is associated with long-term morbidity. We evaluated the efficacy of a low dose of the selective cyclooxygenase-2 inhibitor Nimesulide in preventing human Neuroblastoma tumor growth in Severe Combined Immune-deficient mice. Mice containing established tumors (SH-SY5Y cells) treated with 20 mg/kg Nimesulide every 4th day beginning on day 1 of cell injections resulted in a 65% reduction of tumor growth compared to the DMSO treated control mice (P < 0.05) but did not significantly reduce tumor growth when Nimesulide was started once tumors reached 1cm. There was a reduction in the level of cyclooxygenase-2 protein and induction of effecter caspases in tumors treated with Nimesulide. However, there was no change in the levels of X-Inhibitor-of-Apoptosis-Protein, Smac/Diablo, or proteins of the PI3/Akt pathway following Nimesulide treatment. In Conclusion, low doses of Nimesulide can potentially be used as a chemopreventive agent for human Neuroblastoma.
Original language | English (US) |
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Pages (from-to) | 129-134 |
Number of pages | 6 |
Journal | Journal of Neuro-Oncology |
Volume | 78 |
Issue number | 2 |
DOIs | |
State | Published - Jun 2006 |
Keywords
- Cox-2
- Neuroblastoma
- Nimesulide
- SCID
- XIAP
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research