Inflammatory myofibroblastic tumor of the liver inflammatory myofibroblastic tumor of the liver

Garron J. Solomon, Milan M. Kinkhabwala, Mohammed Akhtar

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


We report a case of hepatic inflammatory myofibroblastic tumor in a 26-year-old African American man who presented with right upper quadrant pain, weight loss, and fatigue during the previous year. Hepatomegaly was found on physical examination. Laboratory findings were significant for mild normocytic, normochromic anemia and elevated erythrocyte sedimentation rate. Imaging studies showed 2 contiguous masses suspicious for malignancy. A left partial hepatectomy was performed; the preoperative differential diagnosis was for angiosarcoma and hepatocellular carcinoma. The resected liver specimen showed 2 contiguous, firm, tan-white nodules that microscopically represented a proliferation of spindled myofibroblast cells set in an inflammatory and collagenized background. The spindle cells were strongly reactive for smooth muscle actin but negative for ALK-1. The morphologic and immunophenotypic findings, coupled with the clinical presentation, were consistent with an inflammatory myofabroblastic tumor of the liver.

Original languageEnglish (US)
Pages (from-to)1548-1551
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Issue number10
StatePublished - Oct 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology


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