Infantile spasms: A U.S. consensus report

John M. Pellock, Richard Hrachovy, Shlomo Shinnar, Tallie Z. Baram, David Bettis, Dennis J. Dlugos, William D. Gaillard, Patricia A. Gibson, Gregory L. Holmes, Douglas R. Nordli, Christine O'Dell, W. Donald Shields, Edwin Trevathan, James W. Wheless

Research output: Contribution to journalReview articlepeer-review

360 Scopus citations


The diagnosis, evaluation, and management of infantile spasms (IS) continue to pose significant challenges to the treating physician. Although an evidence-based practice guideline with full literature review was published in 2004, diversity in IS evaluation and treatment remains and highlights the need for further consensus to optimize outcomes in IS. For this purpose, a working group committed to the diagnosis, treatment, and establishment of a continuum of care for patients with IS and their families-the Infantile Spasms Working Group (ISWG)-was convened. The ISWG participated in a workshop for which the key objectives were to review the state of our understanding of IS, assess the scientific evidence regarding efficacy of currently available therapeutic options, and arrive at a consensus on protocols for diagnostic workup and management of IS that can serve as a guide to help specialists and general pediatricians optimally manage infants with IS. The overall goal of the workshop was to improve IS outcomes by assisting treating physicians with early recognition and diagnosis of IS, initiation of short duration therapy with a first-line treatment, timely electroencephalography (EEG) evaluation of treatment to evaluate effectiveness, and, if indicated, prompt treatment modification. Differences of opinion among ISWG members occurred in areas where data were lacking; however, this article represents a consensus of the U.S. approach to the diagnostic evaluation and treatment of IS.

Original languageEnglish (US)
Pages (from-to)2175-2189
Number of pages15
Issue number10
StatePublished - Oct 2010


  • Adrenocorticotropic hormone
  • Corticosteroids
  • Encephalopathic epilepsy
  • Infantile spasms
  • Treatment
  • Vigabatrin
  • West syndrome

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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