Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Erik Mullaart; Michael E.T.I. Boerrigter; Rivka Ravid; Dick F. Swaab; Jan Vijg

doi:10.1016/0197-4580(90)90542-8

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Erik Mullaart, Michael E.T.I. Boerrigter, Rivka Ravid, Dick F. Swaab, Jan Vijg

Research output: Contribution to journal › Article › peer-review

175 Scopus citations

Abstract

It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

Original language	English (US)
Pages (from-to)	169-173
Number of pages	5
Journal	Neurobiology of Aging
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0197-4580(90)90542-8
State	Published - 1990
Externally published	Yes

Keywords

Alkaline elution
Alzheimer's disease
Cerebral cortex
DNA breaks

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(90)90542-8

Cite this

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title = "Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients",

abstract = "It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.",

keywords = "Alkaline elution, Alzheimer's disease, Cerebral cortex, DNA breaks",

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T1 - Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

AU - Mullaart, Erik

AU - Boerrigter, Michael E.T.I.

AU - Ravid, Rivka

AU - Swaab, Dick F.

AU - Vijg, Jan

PY - 1990

Y1 - 1990

N2 - It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

AB - It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of damage in DNA due to defective DNA-repair (21). Attempts to test this hypothesis by determining the activity of DNA-repair systems in nonneuronal cells from AD patients and controls so far provided conflicting results. An alternative approach is the direct comparison of DNA-damage levels in neuronal tissue of AD patients and controls. In the present study we assayed the level of DNA breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls obtained from rapid autopsies. Our data on 11 AD patients and 8 control subjects indicate an at least two-fold higher level of DNA damage in cortex of AD patients as compared to controls.

KW - Alkaline elution

KW - Alzheimer's disease

KW - Cerebral cortex

KW - DNA breaks

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Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

Abstract

Keywords

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