Increased insulin responsiveness and insulin clearance in thyrotoxicosis

N. Barzilai, P. Cohen, D. Barzilai, E. Karnieli

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The euglycemic insulin clamp technique was used to evaluate in vivo insulin action in thyrotoxicosis (TTX). Insulin was infused at 0.5, 3 and 10 mu/kg per min, and the steady-state glucose infusion rate was determined in five TTX patients with fasting hyperinsulinemia and five healthy subjects. TTX is accompanied by a significant increase in insulin responsiveness, clearance and basal insulin delivery rate. Therefore, insulin resistance in TTX does not reside at the postreceptor peripheral tissue level, but may be the consequence of increased hepatic glucose production.

Original languageEnglish (US)
Pages (from-to)722-726
Number of pages5
JournalIsrael Journal of Medical Sciences
Issue number9
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering


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