Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

Kevin Kalinsky; Emerson A. Lim; Eleni Andreopoulou; Avni M. Desai; Zhezhen Jin; Yifan Tu; Hanina Hibshoosh; Antai Wang; Heather Greenlee; Katherine D. Crew; Matthew Maurer; Joseph A. Sparano; Dawn L. Hershman

doi:10.3109/07357907.2014.958232

Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

Kevin Kalinsky, Emerson A. Lim, Eleni Andreopoulou, Avni M. Desai, Zhezhen Jin, Yifan Tu, Hanina Hibshoosh, Antai Wang, Heather Greenlee, Katherine D. Crew, Matthew Maurer, Joseph A. Sparano, Dawn L. Hershman

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

Original language	English (US)
Pages (from-to)	439-444
Number of pages	6
Journal	Cancer Investigation
Volume	32
Issue number	9
DOIs	https://doi.org/10.3109/07357907.2014.958232
State	Published - Nov 21 2014
Externally published	Yes

Keywords

Breast cancer
Hispanic
Non-Hispanic white
Oncotype DX
Proliferation axis score
Tumor proliferation

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/07357907.2014.958232

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title = "Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer",

abstract = "Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.",

keywords = "Breast cancer, Hispanic, Non-Hispanic white, Oncotype DX, Proliferation axis score, Tumor proliferation",

author = "Kevin Kalinsky and Lim, {Emerson A.} and Eleni Andreopoulou and Desai, {Avni M.} and Zhezhen Jin and Yifan Tu and Hanina Hibshoosh and Antai Wang and Heather Greenlee and Crew, {Katherine D.} and Matthew Maurer and Sparano, {Joseph A.} and Hershman, {Dawn L.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2014 Informa Healthcare USA, Inc.",

year = "2014",

month = nov,

day = "21",

doi = "10.3109/07357907.2014.958232",

language = "English (US)",

volume = "32",

pages = "439--444",

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T1 - Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

AU - Kalinsky, Kevin

AU - Lim, Emerson A.

AU - Andreopoulou, Eleni

AU - Desai, Avni M.

AU - Jin, Zhezhen

AU - Tu, Yifan

AU - Hibshoosh, Hanina

AU - Wang, Antai

AU - Greenlee, Heather

AU - Crew, Katherine D.

AU - Maurer, Matthew

AU - Sparano, Joseph A.

AU - Hershman, Dawn L.

PY - 2014/11/21

Y1 - 2014/11/21

N2 - Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

AB - Hispanic women have higher breast cancer mortality compared to non-Hispanic whites. We evaluated for Proliferation Axis Score differences, as determined by Oncotype Dx, in Hispanic and non-Hispanic white women with newly diagnosed breast cancer. We matched 219 women, based upon age, stage, and nodal status. Compared to non-Hispanic whites, Hispanic women with hormone-sensitive, HER2-negative early-stage breast cancer had a higher Proliferation Axis Score. No differences were seen in Recurrence Score, ER, PR, or HER2 by Oncotype DX. CCNB1 and AURKA were significantly higher in Hispanic women. These tumor differences may help explain breast cancer outcome differences between the two ethnicities.

KW - Breast cancer

KW - Hispanic

KW - Non-Hispanic white

KW - Oncotype DX

KW - Proliferation axis score

KW - Tumor proliferation

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JO - Cancer Investigation

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ER -

Increased expression of tumor proliferation genes in Hispanic women with early-stage breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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