Increased cerebral blood flow during m-CPP exacerbation of obsessive-compulsive disorder

E. Hollander, I. Prohovnik, D. J. Stein

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The partial serotonin agonist m-chlorophenylpiperazine (m-CPP) has been reported to increase obsessive-compulsive symptoms in some patients with obsessive-compulsive disorder (OCD). The authors investigated the underlying physiological mechanisms of this variable exacerbation by imaging regional cerebral blood flow with the planar xenon-133 method after administration of oral m-CPP (0.5 mg/kg). Seven patients who responded to m-CPP with symptomatic exacerbation had a marked increase in global cortical perfusion (18.1%), in contrast to the remaining 7 nonresponders to m-CPP, who showed no change. These results suggest that m-CPP exacerbation of OCD symptoms is associated with increased cortical blood flow.

Original languageEnglish (US)
Pages (from-to)485-490
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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