Abstract
The partial serotonin agonist m-chlorophenylpiperazine (m-CPP) has been reported to increase obsessive-compulsive symptoms in some patients with obsessive-compulsive disorder (OCD). The authors investigated the underlying physiological mechanisms of this variable exacerbation by imaging regional cerebral blood flow with the planar xenon-133 method after administration of oral m-CPP (0.5 mg/kg). Seven patients who responded to m-CPP with symptomatic exacerbation had a marked increase in global cortical perfusion (18.1%), in contrast to the remaining 7 nonresponders to m-CPP, who showed no change. These results suggest that m-CPP exacerbation of OCD symptoms is associated with increased cortical blood flow.
Original language | English (US) |
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Pages (from-to) | 485-490 |
Number of pages | 6 |
Journal | Journal of Neuropsychiatry and Clinical Neurosciences |
Volume | 7 |
Issue number | 4 |
DOIs | |
State | Published - 1995 |
Externally published | Yes |
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health