Abstract
We aimed to investigate the impact of the new kidney allocation system (KAS) on the rate of transplantation of sensitized patients at our center. Pre-KAS and post-KAS intervals were Jan 1st to Dec 3rd 2014 and Jan 1st 2015 to Dec 3rd 2015, respectively. The number of deceased-donor crossmatches performed by flow cytometry increased from 715 pre-KAS to 1188 post-KAS. The percent of crossmatches performed for sensitized patients with calculated panel reactive antibody (cPRA) > 0% increased from 19% pre-KAS to 26% post-KAS (p < 0.0001). The number of deceased-donor kidney transplants performed at our center increased from 115 pre-KAS to 125 post-KAS (9% increase). There was a significant increase in the percentage of deceased-donor kidney transplants received by sensitized candidates (from 14% to 26% pre- and post-KAS, respectively; p < 0.0001). The highest increase was seen in the patients with cPRA > 98%, from 0% to 9%, followed by the group with cPRA 50–79%, from 5% to 8%. This increase was balanced by a decrease of 12% in the percentage of non-sensitized recipients, and a modest decrease of 1% in the group with cPRA 1–49%. In conclusion, transplant rate has increased in sensitized patients after KAS. The highest increase was observed among highly sensitized patients (cPRA > 98%).
Original language | English (US) |
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Pages (from-to) | 257-262 |
Number of pages | 6 |
Journal | Human Immunology |
Volume | 78 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2017 |
Keywords
- HLA sensitization
- Kidney allocation system
- Kidney transplantation
- Panel reactive antibody
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology