Increase in 3-methylhistidine in umbilical cord blood from acidotic fetuses

David Garry, Tolga Kokturk, Reinaldo Figueroa, Dev Maulik, Saul R. Powell

Research output: Contribution to journalArticlepeer-review


OBJECTIVE: To examine the hypothesis that acidotic fetuses at birth have an increased catabolic state characterized by a negative nitrogen balance. STUDY DESIGN: Umbilical cord blood samples were obtained from a random, prospective series of fetuses at birth. Acidotic samples (pH<7.20) were matched with normals (pH≥7.20) according to maternal and gestational age. 3-Methylhistidine was analyzed in order to assess catabolic breakdown of muscle protein. RESULTS: 3-Methylhistidine was significantly increased (P <.05) in cord blood from acidotic fetuses when compared with controls and correlated negatively (P <.05) with umbilical arterial pH. CONCLUSION: Umbilical cord blood 3-methylhistidine may be used to assess fetal nitrogen balance; acidotic fetuses have increased muscle catabolism.

Original languageEnglish (US)
Pages (from-to)675-678
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Issue number8
StatePublished - Aug 1 2002


  • Acidosis
  • Methylhistines
  • Neonate
  • Umbilical cord

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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