In vivo thermal ablation monitoring by echo decorrelation imaging

Swetha Subramanian, Steven M. Rudich, Amel Alqadah, Chandra Priya Karunakaran, T. Douglas Mast

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations


In the studies reported here, the ability of echo decorrelation imaging to predict thermal ablation in vivo is tested. Radiofrequency ablation (RFA) was performed on a normal swine liver (N=5) and ultrasound ablation using image-ablate arrays was performed on a rabbit implanted with VX2 tumors (N=3). Echo decorrelation imaging was able to predict ablation and overtreatment with high accuracy for both RFA and ultrasound ablation. The effect of tissue motion was studied by comparing the mean cumulative decorrelation with and without treatment. The mean cumulative decorrelation with treatment was found to be significantly greater than the mean cumulative decorrelation without treatment (p=0.0347 for RFA, p=0.024 for ultrasound ablation). The accuracy of ablation predictions was tested using receiver operating characteristic curves and the area under the ROC curve (AUROC) was significant for ablation and overtreatment for RFA (N=5). However, the AUROC was significant for only detecting ablation for the ultrasound ablation experiments (N=2).

Original languageEnglish (US)
Title of host publication11th International Symposium on Therapeutic Ultrasound
Number of pages7
StatePublished - 2012
Externally publishedYes
Event11th International Symposium on Therapeutic Ultrasound, ISTU 2011 - New York, NY, United States
Duration: Apr 11 2011Apr 13 2011

Publication series

NameAIP Conference Proceedings
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616


Conference11th International Symposium on Therapeutic Ultrasound, ISTU 2011
Country/TerritoryUnited States
CityNew York, NY


  • Echo decorrelation imaging
  • bulk ultrasound ablation
  • radiofrequency ablation
  • therapy monitoring

ASJC Scopus subject areas

  • Physics and Astronomy(all)


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