Abstract
This study was designed to analyze the complex morphologic and functional effects of dialysis solutions on peritoneum in a rat model on chronic peritoneal dialysis. Peritoneal catheters were inserted into 10 male, Wistar rats and the animals were dialyzed twice daily for 4 weeks with 4.25% Dianeal. During the study we observed two opposite effects: healing of the peritoneum after catheter implantation - decreased cell count in dialysate, decreased permeability of the peritoneum to glucose and total protein, increased volume of drained dialysate; and damage to the membrane due to its exposure to peritoneal dialysis solution - increased hyaluronic acid levels in dialysate, a tendency of the peritoneum to thicken when compared to non- dialyzed animals. Our rat model of CAPD may be used for quantitative and qualitative assessment of the effects of peritoneal dialysis solution on the peritoneum during chronic dialysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 673-677 |
| Number of pages | 5 |
| Journal | International Journal of Artificial Organs |
| Volume | 20 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1997 |
| Externally published | Yes |
Keywords
- Biocompatibility
- Peritoneal dialysis
- Rat model
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Bioengineering
- Biomaterials
- Biomedical Engineering