In vivo imaging of dendritic pruning in dentate granule cells

J. Tiago Gonçalves, Cooper W. Bloyd, Matthew Shtrahman, Stephen T. Johnston, Simon T. Schafer, Sarah L. Parylak, Thanh Tran, Tina Chang, Fred H. Gage

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


We longitudinally imaged the developing dendrites of adult-born mouse dentate granule cells (DGCs) in vivo and found that they underwent over-branching and pruning. Exposure to an enriched environment and constraint of dendritic growth by disrupting Wnt signaling led to increased branch addition and accelerated growth, which were, however, counteracted by earlier and more extensive pruning. Our results indicate that pruning is regulated in a homeostatic fashion to oppose excessive branching and promote a similar dendrite structure in DGCs.

Original languageEnglish (US)
Pages (from-to)788-791
Number of pages4
JournalNature Neuroscience
Issue number6
StatePublished - Apr 26 2016
Externally publishedYes

ASJC Scopus subject areas

  • General Neuroscience


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