TY - JOUR
T1 - In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation
AU - Oktay, K.
AU - Buyuk, E.
AU - Rodriguez-Wallberg, K. A.
AU - Sahin, G.
N1 - Funding Information:
Professor Oktay is supported by a National Institutes of Health Grant ( HD53112 ). Dr Rodriguez-Wallberg is supported by research grants from The Swedish Society of Medical Research and The Swedish Society of Medicine .
PY - 2010/5
Y1 - 2010/5
N2 - This study tested in-vitro maturation (IVM) as a complementary strategy to improve the mature oocyte yield of breast cancer patients undergoing ovarian stimulation for fertility preservation. Secondary analysis of prospectively collected data is performed for 32 breast cancer patients undergoing oocyte or embryo cryopreservation before chemotherapy. Total number of oocytes and/or embryos cryopreserved following IVM is compared with the total number cryopreserved before IVM. Overall, 464 oocytes were retrieved, of which 274 were mature. Following IVM, the number of total mature oocytes increased to 399 (45% increase in mature oocyte yield, P < 0.0001). Fertilization rate after IVM was statistically significantly higher than the fertilization of already mature oocytes at retrieval (86% versus 73%, respectively, P < 0.05). The total number of oocytes and embryos frozen before IVM was 207 (45% of all oocytes retrieved). This number increased to 320 (69% of all oocytes retrieved) following IVM (P < 0.0001 ). IVM is a useful strategy to improve the mature oocyte yield of fertility preservation cycles. Immature oocytes retrieved during oocyte/embryo cryopreservation cycles should not be discarded to improve the future potential of fertility.
AB - This study tested in-vitro maturation (IVM) as a complementary strategy to improve the mature oocyte yield of breast cancer patients undergoing ovarian stimulation for fertility preservation. Secondary analysis of prospectively collected data is performed for 32 breast cancer patients undergoing oocyte or embryo cryopreservation before chemotherapy. Total number of oocytes and/or embryos cryopreserved following IVM is compared with the total number cryopreserved before IVM. Overall, 464 oocytes were retrieved, of which 274 were mature. Following IVM, the number of total mature oocytes increased to 399 (45% increase in mature oocyte yield, P < 0.0001). Fertilization rate after IVM was statistically significantly higher than the fertilization of already mature oocytes at retrieval (86% versus 73%, respectively, P < 0.05). The total number of oocytes and embryos frozen before IVM was 207 (45% of all oocytes retrieved). This number increased to 320 (69% of all oocytes retrieved) following IVM (P < 0.0001 ). IVM is a useful strategy to improve the mature oocyte yield of fertility preservation cycles. Immature oocytes retrieved during oocyte/embryo cryopreservation cycles should not be discarded to improve the future potential of fertility.
KW - Cryopreservation
KW - Embryo
KW - Fertility preservation
KW - In-vitro maturation
KW - Oocyte
UR - http://www.scopus.com/inward/record.url?scp=77952876421&partnerID=8YFLogxK
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U2 - 10.1016/j.rbmo.2010.01.012
DO - 10.1016/j.rbmo.2010.01.012
M3 - Article
C2 - 20219430
AN - SCOPUS:77952876421
SN - 1472-6483
VL - 20
SP - 634
EP - 638
JO - Reproductive BioMedicine Online
JF - Reproductive BioMedicine Online
IS - 5
ER -