In vitro atrial septal ablation using high-intensity focused ultrasound

Yasuyoshi Takei, Robert Muratore, Andrew Kalisz, Kazue Okajima, Kohei Fujimoto, Takuya Hasegawa, Kotaro Arai, Yelena Rekhtman, Grace Berry, Marco R. Di Tullio, Shunichi Homma

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background: High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU. Methods: Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm 2 for 0.4 sec in 1-sec intervals. Results: Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R 2 = 0.3389, P <.0001) and lesion volume (R 2 = 0.6161, P <.0001). Conclusions: HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy.

Original languageEnglish (US)
Pages (from-to)467-472
Number of pages6
JournalJournal of the American Society of Echocardiography
Issue number4
StatePublished - Apr 2012
Externally publishedYes


  • Atrial septum
  • High-intensity focused ultrasound
  • Pulmonary artery hypertension
  • Therapeutic ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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