In search of an "autophagomometer"

David C. Rubinsztein; Ana Maria Cuervo; Brinda Ravikumar; Sovan Sarkar; Viktor Korolchuk; Susmita Kaushik; Daniel J. Klionsky

doi:10.4161/auto.5.5.8823

In search of an "autophagomometer"

David C. Rubinsztein, Ana Maria Cuervo, Brinda Ravikumar, Sovan Sarkar, Viktor Korolchuk, Susmita Kaushik, Daniel J. Klionsky

Developmental & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

493 Scopus citations

Abstract

Recent years have seen the realization that macroautophagy (which we will call autophagy) is not only important in yeast but is necessary for diverse functions in plants and animals. Importantly, autophagy can have an impact on human pathologies including infectious diseases, cancers, and neurodegenerative conditions.1 Thus, we need to be able to measure autophagy accurately in order to understand how it can be regulated physiologically and with exogenous agents.

Original language	English (US)
Pages (from-to)	585-589
Number of pages	5
Journal	Autophagy
Volume	5
Issue number	5
DOIs	https://doi.org/10.4161/auto.5.5.8823
State	Published - Jul 1 2009

Keywords

Assay
Autophagy
Flux
LC3
Synthesis

ASJC Scopus subject areas

Molecular Biology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/auto.5.5.8823

Cite this

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title = "In search of an {"}autophagomometer{"}",

abstract = "Recent years have seen the realization that macroautophagy (which we will call autophagy) is not only important in yeast but is necessary for diverse functions in plants and animals. Importantly, autophagy can have an impact on human pathologies including infectious diseases, cancers, and neurodegenerative conditions.1 Thus, we need to be able to measure autophagy accurately in order to understand how it can be regulated physiologically and with exogenous agents.",

keywords = "Assay, Autophagy, Flux, LC3, Synthesis",

author = "Rubinsztein, {David C.} and Cuervo, {Ana Maria} and Brinda Ravikumar and Sovan Sarkar and Viktor Korolchuk and Susmita Kaushik and Klionsky, {Daniel J.}",

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language = "English (US)",

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T1 - In search of an "autophagomometer"

AU - Rubinsztein, David C.

AU - Cuervo, Ana Maria

AU - Ravikumar, Brinda

AU - Sarkar, Sovan

AU - Korolchuk, Viktor

AU - Kaushik, Susmita

AU - Klionsky, Daniel J.

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Recent years have seen the realization that macroautophagy (which we will call autophagy) is not only important in yeast but is necessary for diverse functions in plants and animals. Importantly, autophagy can have an impact on human pathologies including infectious diseases, cancers, and neurodegenerative conditions.1 Thus, we need to be able to measure autophagy accurately in order to understand how it can be regulated physiologically and with exogenous agents.

AB - Recent years have seen the realization that macroautophagy (which we will call autophagy) is not only important in yeast but is necessary for diverse functions in plants and animals. Importantly, autophagy can have an impact on human pathologies including infectious diseases, cancers, and neurodegenerative conditions.1 Thus, we need to be able to measure autophagy accurately in order to understand how it can be regulated physiologically and with exogenous agents.

KW - Assay

KW - Autophagy

KW - Flux

KW - LC3

KW - Synthesis

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UR - http://www.scopus.com/inward/citedby.url?scp=67650222474&partnerID=8YFLogxK

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DO - 10.4161/auto.5.5.8823

M3 - Review article

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JO - Autophagy

JF - Autophagy

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ER -

In search of an "autophagomometer"

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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