Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction

Aleksandr Rovner, Rebecca Smith, Neil L. Greenberg, E. Murat Tuzcu, Nicholas Smedira, Harry M. Lever, James D. Thomas, Mario J. Garcia

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


We sought to validate measurement of intraventricular pressure gradients (IVPG) and analyze their change in patients with hypertrophic obstructive cardiomyopathy (HOCM) after ethanol septal reduction (ESR). Quantitative analysis of color M-mode Doppler (CMM) images may be used to estimate diastolic IVPG noninvasively. Noninvasive IVPG measurement was validated in 10 patients undergoing surgical myectomy. Echocardiograms were then analyzed in 19 patients at baseline and after ESR. Pulsed Doppler data through the mitral valve and pulmonary venous flow were obtained. CMM was used to obtain the flow propagation velocity (Vp) and to calculate IVPG off-line. Left atrial pressure was estimated with the use of previously validated Doppler equations. Data were compared before and after ESR. CMM-derived IVPG correlated well with invasive measurements obtained before and after surgical myectomy [r = 0.8, P < 0.01, δ(CMM - invasive IVPG) = 0.09 ± 0.45 mmHg]. ESR resulted in a decrease of resting LVOT systolic gradient from 62 ± 10 to 29 ± 5 mmHg (P < 0.001). There was a significant increase in the Vp and IVPG (from 48 ± 5 to 74 ± 7 cm/s and from 1.5 ± 0.2 to 2.6 ± 0.3 mmHg, respectively, P < 0.001 for both). Estimated left atrial pressure decreased from 16.2 ± 1.1 to 11.5 ± 0.9 mmHg (P < 0.001). The increase in IVPG correlated with the reduction in the LVOT gradient (r = 0.6, P < 0.01). Reduction of LVOT obstruction after ESR is associated with an improvement in diastolic suction force. Noninvasive measurements of IVPG may be used as an indicator of diastolic function improvement in HOCM.

Original languageEnglish (US)
Pages (from-to)H2492-H2499
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 54-6
StatePublished - Dec 2003
Externally publishedYes


  • Diastolic function
  • Echocardiography
  • Hypertrophic obstructive cardiomyopathy

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


Dive into the research topics of 'Improvement in diastolic intraventricular pressure gradients in patients with HOCM after ethanol septal reduction'. Together they form a unique fingerprint.

Cite this