Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy

Howard E. Corey; Vivian Tellis; Richard Schechner; Stuart M. Greenstein

doi:10.1007/s004670050198

Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy

Howard E. Corey, Vivian Tellis, Richard Schechner, Stuart M. Greenstein

Surgery

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

FK 506 has been reported to be effective in reversing acute renal allograft rejection that is resistant to steroids and to OKT3. The contribution of FK 506 'rescue' therapy to long-term graft survival has not been determined. We report 23 children transplanted between January 1993 and December 1994, 10 of whom received FK 506 'rescue' therapy. Acute rejection was reversed in 8 of 10, with 7 of the remaining grafts still functioning after a mean follow-up of 10.9 ± 7.8 (SD) months (range 1-26 months). The actuarial 1-year graft survival rate was 86% compared with 66% for historical, controls (P < 0.05). We conclude that FK 506 may provide long-term benefits to children facing allograft loss due to acute rejection.

Original language	English (US)
Pages (from-to)	720-722
Number of pages	3
Journal	Pediatric Nephrology
Volume	10
Issue number	6
DOIs	https://doi.org/10.1007/s004670050198
State	Published - 1996

Keywords

Allograft rejection
FK 506

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Nephrology

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10.1007/s004670050198

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abstract = "FK 506 has been reported to be effective in reversing acute renal allograft rejection that is resistant to steroids and to OKT3. The contribution of FK 506 'rescue' therapy to long-term graft survival has not been determined. We report 23 children transplanted between January 1993 and December 1994, 10 of whom received FK 506 'rescue' therapy. Acute rejection was reversed in 8 of 10, with 7 of the remaining grafts still functioning after a mean follow-up of 10.9 ± 7.8 (SD) months (range 1-26 months). The actuarial 1-year graft survival rate was 86% compared with 66% for historical, controls (P < 0.05). We conclude that FK 506 may provide long-term benefits to children facing allograft loss due to acute rejection.",

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AU - Tellis, Vivian

AU - Schechner, Richard

AU - Greenstein, Stuart M.

PY - 1996

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AB - FK 506 has been reported to be effective in reversing acute renal allograft rejection that is resistant to steroids and to OKT3. The contribution of FK 506 'rescue' therapy to long-term graft survival has not been determined. We report 23 children transplanted between January 1993 and December 1994, 10 of whom received FK 506 'rescue' therapy. Acute rejection was reversed in 8 of 10, with 7 of the remaining grafts still functioning after a mean follow-up of 10.9 ± 7.8 (SD) months (range 1-26 months). The actuarial 1-year graft survival rate was 86% compared with 66% for historical, controls (P < 0.05). We conclude that FK 506 may provide long-term benefits to children facing allograft loss due to acute rejection.

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Improved renal allograft survival in children treated with FK 506 (tacrolimus) rescue therapy

Abstract

Keywords

ASJC Scopus subject areas

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