Improved anamnestic response among adolescents boosted with a higher dose of the hepatitis B vaccine

Sandra S. Chaves, Justina Groeger, Louisa Helgenberger, Steven B. Auerbach, Stephanie R. Bialek, Dale J. Hu, Jan Drobeniuc

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Some hepatitis B vaccine booster studies have suggested waning of vaccine-induced immunity in adolescents vaccinated starting at birth. Those studies, however, used a pediatric formulation of the hepatitis B vaccine as a booster to detect anamnestic response. We compared adolescents boosted with an adult dose of hepatitis B vaccine with those boosted with a pediatric dose. Among adolescents who had lost protective antibody levels against hepatitis B, a higher proportion had an anamnestic response when boosted with the adult dose (60.0% vs. 43.8%). Thus, higher antigen concentrations may be required to elicit an adequate immune memory response. Despite improved anamnestic response, our study still raises concerns about whether children immunized in early infancy will remain protected from hepatitis B as they age into adulthood.

Original languageEnglish (US)
Pages (from-to)2860-2864
Number of pages5
Issue number16
StatePublished - Apr 1 2010
Externally publishedYes


  • Anamnestic response
  • Hepatitis B vaccination
  • Hepatitis B virus
  • Long term immunity

ASJC Scopus subject areas

  • Molecular Medicine
  • General Immunology and Microbiology
  • General Veterinary
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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