Impact of periprocedural colchicine on postprocedural management in patients undergoing a left atrial appendage ligation using LARIAT

Sampath Gunda, Madhu Reddy, Jayant Nath, Hosakote Nagaraj, Moustapha Atoui, Abdi Rasekh, Christopher R. Ellis, Nitish Badhwar, Randall J. Lee, Luigi Di Biase, Moussa Mansour, Jeremy N. Ruskin, Andrea Natale, Matthew Earnest, Dhanunjaya R. Lakkireddy

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Periprocedural Colchicine for Epicardial Access Procedures Introduction Left atrial appendage (LAA) can be effectively and safely excluded using a novel percutaneous LARIAT ligation system. However, due to pericardial catheter manipulation and LAA ligation and subsequent necrosis, postprocedural course is complicated by pericarditis. We intended to evaluate the preprocedural use of colchicine on the incidence of postprocedural pericardial complications. Methods and Results In this multicenter observational study, we included all consecutive patients who underwent LARIAT procedure at the participating centers. Many patients received periprocedural colchicine at the discretion of the physician. We compared the postprocedural outcomes of patients who received prophylactic periprocedural colchicine (colchicine group) with those who did not receive colchicine (standard group). A total of 344 consecutive patients, 243 in the "colchicine group" and 101 in the "standard group," were included. The mean age, median CHADS2VASc score, and HASBLED scores were 70 ± 11 years, 3 ± 1.7, and 3 ± 1.1, respectively. There were no significant differences in major baseline characteristics between the two groups. Severe pericarditis was significantly lower in the "colchicine group" compared to the "standard group" (10 [4%] vs. 16 [16%] P<0.0001). The colchicine group, compared to the standard group, had lesser pericardial drain output (186 ± 84 mL vs. 351 ± 83, P<0.001), shorter pericardial drain duration (16 ± 4 vs. 23 ± 19 hours, P<0.04), and similar incidence of delayed pericardial effusion (4 [1.6%] to 3 [3%], P = 0.42) when compared to the standard group. Conclusion Use of colchicine periprocedurally was associated with significant reduction in postprocedural pericarditis and associated complications.

Original languageEnglish (US)
Pages (from-to)60-64
Number of pages5
JournalJournal of cardiovascular electrophysiology
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • LARIAT procedure
  • atrial fibrillation
  • colchicine
  • left atrial appendage
  • pericarditis
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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