Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration

Yanping Cheng; Marco Ferrone; Qing Wang; Laura E.L. Perkins; Jennifer McGregor; Björn Redfors; Zhipeng Zhou; Richard Rapoza; Gerard B. Conditt; Aloke Finn; Renu Virmani; Grzegorz L. Kaluza; Juan F. Granada

doi:10.1016/j.jacbts.2020.04.005

Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration

Yanping Cheng, Marco Ferrone, Qing Wang, Laura E.L. Perkins, Jennifer McGregor, Björn Redfors, Zhipeng Zhou, Richard Rapoza, Gerard B. Conditt, Aloke Finn, Renu Virmani, Grzegorz L. Kaluza, Juan F. Granada

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The integration of the Absorb bioresorbable vascular scaffold (BVS) into the arterial wall has never been tested in an in vivo model of atherosclerosis. This study aimed to compare the long-term (up to 4 years) vascular healing responses of BVS to an everolimus-eluting metallic stent in the familial hypercholesterolemic swine model of atherosclerosis. The multimodality imaging and histology approaches indicate that the resorption and vascular integration profile of BVS is not affected by the presence of atherosclerosis. BVS demonstrated comparable long-term vascular healing and anti-restenotic efficacy to everolimus-eluting metallic stent but resulted in lower late lumen loss at 4 years.

Original language	English (US)
Pages (from-to)	619-629
Number of pages	11
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	6
DOIs	https://doi.org/10.1016/j.jacbts.2020.04.005
State	Published - Jun 2020
Externally published	Yes

Keywords

bioresorbable vascular scaffolds
familial hypercholesterolemic swine
metallic drug-eluting stents
neoatherosclerosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2020.04.005

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Cheng, Y., Ferrone, M., Wang, Q., Perkins, L. E. L., McGregor, J., Redfors, B., Zhou, Z., Rapoza, R., Conditt, G. B., Finn, A., Virmani, R., Kaluza, G. L., & Granada, J. F. (2020). Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration. JACC: Basic to Translational Science, 5(6), 619-629. https://doi.org/10.1016/j.jacbts.2020.04.005

Cheng, Y, Ferrone, M, Wang, Q, Perkins, LEL, McGregor, J, Redfors, B, Zhou, Z, Rapoza, R, Conditt, GB, Finn, A, Virmani, R, Kaluza, GL & Granada, JF 2020, 'Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration', JACC: Basic to Translational Science, vol. 5, no. 6, pp. 619-629. https://doi.org/10.1016/j.jacbts.2020.04.005

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title = "Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration",

abstract = "The integration of the Absorb bioresorbable vascular scaffold (BVS) into the arterial wall has never been tested in an in vivo model of atherosclerosis. This study aimed to compare the long-term (up to 4 years) vascular healing responses of BVS to an everolimus-eluting metallic stent in the familial hypercholesterolemic swine model of atherosclerosis. The multimodality imaging and histology approaches indicate that the resorption and vascular integration profile of BVS is not affected by the presence of atherosclerosis. BVS demonstrated comparable long-term vascular healing and anti-restenotic efficacy to everolimus-eluting metallic stent but resulted in lower late lumen loss at 4 years.",

keywords = "bioresorbable vascular scaffolds, familial hypercholesterolemic swine, metallic drug-eluting stents, neoatherosclerosis",

author = "Yanping Cheng and Marco Ferrone and Qing Wang and Perkins, {Laura E.L.} and Jennifer McGregor and Bj{\"o}rn Redfors and Zhipeng Zhou and Richard Rapoza and Conditt, {Gerard B.} and Aloke Finn and Renu Virmani and Kaluza, {Grzegorz L.} and Granada, {Juan F.}",

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month = jun,

doi = "10.1016/j.jacbts.2020.04.005",

language = "English (US)",

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AU - Cheng, Yanping

AU - Ferrone, Marco

AU - Wang, Qing

AU - Perkins, Laura E.L.

AU - McGregor, Jennifer

AU - Redfors, Björn

AU - Zhou, Zhipeng

AU - Rapoza, Richard

AU - Conditt, Gerard B.

AU - Finn, Aloke

AU - Virmani, Renu

AU - Kaluza, Grzegorz L.

AU - Granada, Juan F.

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AB - The integration of the Absorb bioresorbable vascular scaffold (BVS) into the arterial wall has never been tested in an in vivo model of atherosclerosis. This study aimed to compare the long-term (up to 4 years) vascular healing responses of BVS to an everolimus-eluting metallic stent in the familial hypercholesterolemic swine model of atherosclerosis. The multimodality imaging and histology approaches indicate that the resorption and vascular integration profile of BVS is not affected by the presence of atherosclerosis. BVS demonstrated comparable long-term vascular healing and anti-restenotic efficacy to everolimus-eluting metallic stent but resulted in lower late lumen loss at 4 years.

KW - bioresorbable vascular scaffolds

KW - familial hypercholesterolemic swine

KW - metallic drug-eluting stents

KW - neoatherosclerosis

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Impact of Coronary Atherosclerosis on Bioresorbable Vascular Scaffold Resorption and Vessel Wall Integration

Abstract

Keywords

ASJC Scopus subject areas

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