Impact of chest pain evaluation program on early thrombolysis in acute myocardial infarction

J. Cosico, L. Kunkel, R. Wharton, M. Menegus, K. Hemingway, M. Goldberger, M. Salomon, H. Mueller

Research output: Contribution to journalArticlepeer-review


Early thrombolysis has increased survival in eligible patients with acute myocardial infarction (AMI). Therefore, early triage and short Door-To-Needle Time [DTNT, time of patient arrival in Emergency Department (ED) to time of thrombolysis] are most important. In a high volume tertiary care center (>500 beds), prompt attention to AMI patients can be delayed. Thus, we developed a Chest Pain Evaluation Program (CPEP). Prospective data on DTNT of consecutive thrombolysis treated patients prior to and after initiation of the CPEP are presented in 3 groups (GR). Pre-CPEP CPEP GR 1IN=45) GR 2(N=36) GR 3(N=36) Study Period 7/93-7/94 8/94-3/95 3/95-11/95 Median (min) 71 57 40 Range (min) 31-221 21-116 15-136 Two-Tailed P <0.03' <0.01 25,75th perc.(min) 50/98 38/73 29/58 Mann-Whitney U test; TGR1 vs GR 2; 'GR2 vs GR3; 'percentile Patients receiving thrombolysis above the 75th perc. of DTNT were considered "outliers", and observed 11x(GR1), 9x(GR2), and 9x(GR3). Causes of outliers were one or a combination of factors, as delay in 1) obtaining ECG (n=8), 2) diagnosis of AMI (n=10), and 3) decision for thrombolysis (n=23). Conclusion: CPEP has significantly decreased DTNT. Major determinants were systematic education of ED triage personnel and of responsible ED physician/nurse team, further, establishment of an in-hospital "911 system", to provide immediate cardiology service.

Original languageEnglish (US)
Pages (from-to)288a
JournalJournal of Investigative Medicine
Issue number3
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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