Immunobiology of acute leukemia

Elisabeth Paietta

doi:10.1007/978-3-319-64263-5_15

Immunobiology of acute leukemia

Elisabeth Paietta

Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

Amidst the genomic revolution in the characterization of the acute leukemias, immunophenotyping maintains a crucial position in diagnosis, determination of therapy, and monitoring of response to therapy. Lineage determination by multiparameter flow cytometry (MFC), the definition of surrogate marker profiles for genetic lesions which guides molecular analysis towards selective, thus limited, testing, MFC for universal MRD detection, monitoring of specific antigen expression targeted by monoclonal antibodies, and characterization of antigens which are associated with prognostically significant somatic mutations all provide valuable attributes to the comprehensive workup of the acute leukemia patient.

Original language	English (US)
Title of host publication	Neoplastic Diseases of the Blood
Publisher	Springer International Publishing
Pages	237-279
Number of pages	43
ISBN (Electronic)	9783319642635
ISBN (Print)	9783319642628
DOIs	https://doi.org/10.1007/978-3-319-64263-5_15
State	Published - Jan 1 2018

Keywords

Flow cytometry
Novel classification
Surrogate marker acute leukemia subtypes

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-3-319-64263-5_15

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Immunobiology of acute leukemia

Abstract

Keywords

ASJC Scopus subject areas

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