Abstract
Mycobacterium tuberculosis is successful as a pathogen because of its ability to persist in an immunocompetent host. This bacterium lives within the macrophage, a cell whose function is the elimination of microbes. Recent advances have improved our understanding of how M. tuberculosis evades two major antimicrobial mechanisms of macrophages: phagolysosome fusion and the production of toxic reactive nitrogen intermediates. M. tuberculosis also modulates antigen presentation to prevent the detection of infected macrophages by CD4+ T cells.
Original language | English (US) |
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Pages (from-to) | 450-455 |
Number of pages | 6 |
Journal | Current Opinion in Immunology |
Volume | 15 |
Issue number | 4 |
DOIs | |
State | Published - Jun 2003 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology