Imaging spectrum of immunomodulating, chemotherapeutic and radiation therapy-related intracranial effects

Christie M. Lincoln, Peter Fata, Susan Sotardi, Michael Pohlen, Tomas Uribe, Jacqueline A. Bello

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Objective: A wide range of treatment-related side effects result in specific neurologic symptoms and signs and neuroimaging features. Even to the most seasoned neuroradiologist, elucidating therapy-related side effects from other common mimics can be challenging. We provide a pictorial survey of some common and uncommon medication-induced and therapy-related neuroimaging manifestations, discuss pathophysiology and common pitfalls in imaging and diagnosis. Methods: A case-based review is utilized to depict scenarios on a routine basis in a general radiology or neuroradiology practice such as medication-induced posterior reversible encephalopathy syndrome to the more challenging cases of pseudoprogression and pseudoregression in temozolmide and bevacizumab therapy in gliobastoma treatment protocols. Conclusion: Knowledge of the treatment-induced imaging abnormalities is essential in the accurate interpretation and diagnosis from the most routine to most challenging of clinical situations. We provide a pictorial review for the radiologist to employ in order to be an invaluable provider to our clinical colleagues and patients.

Original languageEnglish (US)
Article number20170553
JournalBritish Journal of Radiology
Issue number1082
StatePublished - 2018

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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