Abstract
Objective: To describe the neuropathologic findings and clinical course of 2 patients who underwent temporal lobectomy for medically refractive epilepsy and were later found to have high anti-glutamic acid decarboxylase (GAD) concentrations. Methods: Small case series. Results: Neuropathologic examination of both patients revealed International League Against Epilepsy (ILAE) type 3 hippocampal sclerosis. Following surgery, both developed signs and symptoms of stiff person syndrome and later cerebellar ataxia. Laboratory studies demonstrated high concentrations of anti-GAD antibodies in both patients. Conclusions: These cases suggest that ILAE type 3 hippocampal sclerosis may be immunologically related to and may exist as part of a broader anti-GAD-related neurologic syndrome in some instances.
Original language | English (US) |
---|---|
Article number | e122 |
Journal | Neurology: Neuroimmunology and NeuroInflammation |
Volume | 2 |
Issue number | 4 |
DOIs | |
State | Published - 2015 |
ASJC Scopus subject areas
- Neurology
- Clinical Neurology