ILAE type 3 hippocampal sclerosis in patients with anti-GAD - Related epilepsy

Robert L. Glover, Lauren V. De Niro, Patrick A. Lasala, Karen M. Weidenheim, Jerome J. Graber, Alexis Boro

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: To describe the neuropathologic findings and clinical course of 2 patients who underwent temporal lobectomy for medically refractive epilepsy and were later found to have high anti-glutamic acid decarboxylase (GAD) concentrations. Methods: Small case series. Results: Neuropathologic examination of both patients revealed International League Against Epilepsy (ILAE) type 3 hippocampal sclerosis. Following surgery, both developed signs and symptoms of stiff person syndrome and later cerebellar ataxia. Laboratory studies demonstrated high concentrations of anti-GAD antibodies in both patients. Conclusions: These cases suggest that ILAE type 3 hippocampal sclerosis may be immunologically related to and may exist as part of a broader anti-GAD-related neurologic syndrome in some instances.

Original languageEnglish (US)
Article numbere122
JournalNeurology: Neuroimmunology and NeuroInflammation
Issue number4
StatePublished - 2015

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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