IGF2 signaling and regulation in cancer

Jurriaan Brouwer-Visser; Gloria S. Huang

doi:10.1016/j.cytogfr.2015.01.002

IGF2 signaling and regulation in cancer

Jurriaan Brouwer-Visser, Gloria S. Huang

Research output: Contribution to journal › Short survey › peer-review

83 Scopus citations

Abstract

Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is developmentally regulated; however, malignant tissues are characterized by re-activation of the fetal IGF2 promoters, especially P3. In this review, we describe the mechanisms of IGF2 signaling and regulation in normal and malignant tissues and their clinical implications.

Original language	English (US)
Pages (from-to)	371-377
Number of pages	7
Journal	Cytokine and Growth Factor Reviews
Volume	26
Issue number	3
DOIs	https://doi.org/10.1016/j.cytogfr.2015.01.002
State	Published - Jun 1 2015
Externally published	Yes

Keywords

Cancer
Chemoresistance
IGF2

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cytogfr.2015.01.002

Cite this

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title = "IGF2 signaling and regulation in cancer",

abstract = "Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is developmentally regulated; however, malignant tissues are characterized by re-activation of the fetal IGF2 promoters, especially P3. In this review, we describe the mechanisms of IGF2 signaling and regulation in normal and malignant tissues and their clinical implications.",

keywords = "Cancer, Chemoresistance, IGF2",

author = "Jurriaan Brouwer-Visser and Huang, {Gloria S.}",

note = "Funding Information: Grant support was provided by the National Cancer Institute-National Institute of Child Health and Human Development ( K12 HD000849 ) and the American Congress of Obstetricians and Gynecologists through the Reproductive Scientist Development Program award to G.S.H. Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = jun,

day = "1",

doi = "10.1016/j.cytogfr.2015.01.002",

language = "English (US)",

volume = "26",

pages = "371--377",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier BV",

number = "3",

}

TY - JOUR

T1 - IGF2 signaling and regulation in cancer

AU - Brouwer-Visser, Jurriaan

AU - Huang, Gloria S.

N1 - Funding Information: Grant support was provided by the National Cancer Institute-National Institute of Child Health and Human Development ( K12 HD000849 ) and the American Congress of Obstetricians and Gynecologists through the Reproductive Scientist Development Program award to G.S.H. Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is developmentally regulated; however, malignant tissues are characterized by re-activation of the fetal IGF2 promoters, especially P3. In this review, we describe the mechanisms of IGF2 signaling and regulation in normal and malignant tissues and their clinical implications.

AB - Upregulation of IGF2 occurs in both childhood and adult malignancies. Its overexpresssion is associated with resistance to chemotherapy and worse prognosis. IGF2 promoter usage is developmentally regulated; however, malignant tissues are characterized by re-activation of the fetal IGF2 promoters, especially P3. In this review, we describe the mechanisms of IGF2 signaling and regulation in normal and malignant tissues and their clinical implications.

KW - Cancer

KW - Chemoresistance

KW - IGF2

UR - http://www.scopus.com/inward/record.url?scp=84929654387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84929654387&partnerID=8YFLogxK

U2 - 10.1016/j.cytogfr.2015.01.002

DO - 10.1016/j.cytogfr.2015.01.002

M3 - Short survey

C2 - 25704323

AN - SCOPUS:84929654387

SN - 1359-6101

VL - 26

SP - 371

EP - 377

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 3

ER -

IGF2 signaling and regulation in cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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