Abstract
We present two young children ages 24 and 33 months who experienced regression of developmental milestones mimicking a neurodegenerative disorder after being prescribed phenobarbital for treatment of seizures. Phenobarbital levels were not elevated, and there were no other signs of phenobarbital toxicity. Symptoms resolved after discontinuation of phenobarbital therapy. Both children were neurologically abnormal at baseline. The current report adds to the growing list of potential adverse effects of antiepileptic drugs on development and cognition.
Original language | English (US) |
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Pages (from-to) | 34-37 |
Number of pages | 4 |
Journal | Journal of Epilepsy |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - 1994 |
Keywords
- Antiepileptic drug therapy
- Drug toxicity
- Epilepsy
- Pediatrics
- Phenobarbital
- Seizures
ASJC Scopus subject areas
- General Neuroscience
- Clinical Neurology