Idiosyncratic phenobarbital toxicity mimicking a neurodegenerative disorder

Shlomo Shinnar; Harriet Kang

doi:10.1016/0896-6974(94)90117-1

Idiosyncratic phenobarbital toxicity mimicking a neurodegenerative disorder

Shlomo Shinnar, Harriet Kang

Neurology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We present two young children ages 24 and 33 months who experienced regression of developmental milestones mimicking a neurodegenerative disorder after being prescribed phenobarbital for treatment of seizures. Phenobarbital levels were not elevated, and there were no other signs of phenobarbital toxicity. Symptoms resolved after discontinuation of phenobarbital therapy. Both children were neurologically abnormal at baseline. The current report adds to the growing list of potential adverse effects of antiepileptic drugs on development and cognition.

Original language	English (US)
Pages (from-to)	34-37
Number of pages	4
Journal	Journal of Epilepsy
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0896-6974(94)90117-1
State	Published - 1994

Keywords

Antiepileptic drug therapy
Drug toxicity
Epilepsy
Pediatrics
Phenobarbital
Seizures

ASJC Scopus subject areas

General Neuroscience
Clinical Neurology

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10.1016/0896-6974(94)90117-1

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title = "Idiosyncratic phenobarbital toxicity mimicking a neurodegenerative disorder",

abstract = "We present two young children ages 24 and 33 months who experienced regression of developmental milestones mimicking a neurodegenerative disorder after being prescribed phenobarbital for treatment of seizures. Phenobarbital levels were not elevated, and there were no other signs of phenobarbital toxicity. Symptoms resolved after discontinuation of phenobarbital therapy. Both children were neurologically abnormal at baseline. The current report adds to the growing list of potential adverse effects of antiepileptic drugs on development and cognition.",

keywords = "Antiepileptic drug therapy, Drug toxicity, Epilepsy, Pediatrics, Phenobarbital, Seizures",

author = "Shlomo Shinnar and Harriet Kang",

note = "Funding Information: Acknowledgment: This work was supported in part by grant I R01 NS26151 (S.S.) from the National Institute of Neurological Disorders and Stroke. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

year = "1994",

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AU - Kang, Harriet

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Y1 - 1994

N2 - We present two young children ages 24 and 33 months who experienced regression of developmental milestones mimicking a neurodegenerative disorder after being prescribed phenobarbital for treatment of seizures. Phenobarbital levels were not elevated, and there were no other signs of phenobarbital toxicity. Symptoms resolved after discontinuation of phenobarbital therapy. Both children were neurologically abnormal at baseline. The current report adds to the growing list of potential adverse effects of antiepileptic drugs on development and cognition.

AB - We present two young children ages 24 and 33 months who experienced regression of developmental milestones mimicking a neurodegenerative disorder after being prescribed phenobarbital for treatment of seizures. Phenobarbital levels were not elevated, and there were no other signs of phenobarbital toxicity. Symptoms resolved after discontinuation of phenobarbital therapy. Both children were neurologically abnormal at baseline. The current report adds to the growing list of potential adverse effects of antiepileptic drugs on development and cognition.

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KW - Drug toxicity

KW - Epilepsy

KW - Pediatrics

KW - Phenobarbital

KW - Seizures

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Idiosyncratic phenobarbital toxicity mimicking a neurodegenerative disorder

Abstract

Keywords

ASJC Scopus subject areas

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